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September 10, 2025Jentashapir Journal of Cellular and Molecular BiologyOpen Access

Cytotoxic Effects of Escitalopram on MCF7 Breast Cancer Cells and Normal Hek293 Cells

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Authors

ADAtefeh DehghaniSPSanaz PashapourKSKeivan Sheikhi

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Overview

Observational analysis revealed significant cytotoxic effects on MCF7 breast cancer and HEK293 normal cells, suggesting potential implications for treatment strategies.

Key Points

  • Escitalopram significantly reduces MCF7 cell viability at concentrations of 62.5, 125, 250, and 500 µM, and also affects normal HEK293 cells.
  • A decrease in cell viability was observed at high concentrations, with P values indicating statistical significance at less than 0.001 for both cell types.
  • Treatment involved various escitalopram concentrations assessed via MTT assay and gene expression analysis conducted through RT-PCR.
  • The regulation of the BAX gene in MCF7 cells highlights potential mechanisms and off-target effects of escitalopram that require further study.

Cite This Study

Dehghani et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478b2cbhttps://doi.org/10.5812/jjcmb-160110
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Also Consider

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  1. 1Escitalopram and functional connectivity in major depressive disorder: A systematic review2025
  2. 2Effectiveness and safety of escitalopram treatment personalized based on therapeutic drug monitoring of drug plasma concentration: a prospective cohort study2025 · 1 citations
  3. 3Evaluation of the Effect of Escitalopram on Alveolar Bone Levels and Periodontal Parameters: A Case–Control Study2025 · 1 citations
  4. 4Dose-dependent cytotoxicity effect of Aspirin on MCF7 cell line proliferation2023
  5. 5Stability Indicating Spectrofluorimetric Method for the Estimation of Escitalopram in Bulk and Pharmaceutical Dosage Form2025