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July 21, 2025Open Access

Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons

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Authors

AEAmanda EssohHGHimanshu GangalZHZhenbo Huang

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Overview

Experiments show alcohol reduces CRF-induced changes in cholinergic interneurons in the dorsal striatum, indicating effects on reward signaling.

Key Points

  • Alcohol alters the excitatory influence of corticotropin-releasing factor on cholinergic interneurons.
  • Investigation utilized monosynaptic tracing to reveal connectivity between CRF neurons and striatal circuits.
  • Cholinergic interneurons were found to express CRF receptor 1, indicating sensitivity to CRF signaling.
  • Discovering the interaction between CRF and alcohol contributes to understanding stress effects on reward pathways.

Cite This Study

Essoh et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd529https://doi.org/10.7554/elife.107145.1
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