Proteome‐Guided Drug Target Discovery for Periodontitis

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Three proteins—FGF2, AZGP1, and BTC—are causally associated with periodontitis, indicating their potential as drug targets.
Among 2088 proteins evaluated, associations were confirmed for 18, and 16 proteins showed significant colocalization.
Integration of proteomics data with GWAS from the Million Veteran Program facilitated discovery of meaningful connections.
Potential therapeutic relevance is underscored, with links to existing therapies for inflammatory conditions.

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Observational analysis identified three proteins linked to periodontitis, suggesting novel drug targets.

Alayash et al. (2025) studied this question.

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