October 15, 2025Scientific ReportsOpen Access

Single-cell RNA sequencing and Mendelian randomization, revealing molecular mechanisms and causal correlation of immune-related genes in periodontitis

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Identified seven hub genes demonstrating significant causal associations with periodontitis pathogenesis.
Single-cell RNA sequencing data revealed 23 distinct immunological cell populations linked to immune responses in periodontitis.
Mendelian randomization analysis found key genes that influence periodontitis risk, leading to insights into therapeutic targets.
Immunohistochemistry validation confirmed gene expression patterns align with computational predictions of their roles.

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This analysis reveals causal correlations and critical pathways in immune-related genes for periodontitis, indicating new directions for research.

Qiu et al. (2025) studied this question.

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This analysis reveals causal correlations and critical pathways in immune-related genes for periodontitis, indicating new directions for research.