Boswellic Acid and Carnosine Ameliorate Vanadyl-Sulfate-Induced Renal Damage via Regulating Nrf2/HO-1 and PI3K/AKT Pathways

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Observational analysis shows boswellic and carnosic acids reduce nephrotoxicity in rats, suggesting beneficial pathways involving Nrf2 and PI3K.

Boswellic acid and carnosic acid reduce nephrotoxicity caused by vanadyl sulfate in rats.
Treatment led to reduced renal damage markers, resulting in lower levels of creatinine and blood urea.
The study used 30 male Wistar albino rats divided into groups receiving vanadyl sulfate with or without treatment.
These findings support potential therapeutic roles of Nrf2 and PI3K pathways in kidney health.

Gad et al. (2025) studied this question.

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Observational analysis shows boswellic and carnosic acids reduce nephrotoxicity in rats, suggesting beneficial pathways involving Nrf2 and PI3K.