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September 10, 2025Heart Lung and CirculationOpen Access

Obesity and Atrial Fibrillation: From Mechanisms to Treatment

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Authors

JDJenelle DzianoJAJonathan P. AriyaratnamMMMelissa E. Middeldorp

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Overview

This review highlights the connection between obesity and atrial fibrillation, emphasizing treatment strategies and coexisting conditions. It discusses how obesity exacerbates risk factors affecting atrial fibrillation.

Key Points

  • Obesity significantly increases the risk of atrial fibrillation through multiple mechanisms, including cardiac loading and inflammation.
  • Weight loss has been shown to reduce the recurrence of symptomatic atrial fibrillation, emphasizing its importance in treatment strategies.
  • Obesity often coexists with other chronic conditions such as hypertension and type 2 diabetes, exacerbating the burden of atrial fibrillation.
  • Emerging pharmacological treatments for obesity may provide new avenues for managing atrial fibrillation in affected patients.

Cite This Study

Dziano et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d64787780https://doi.org/10.1016/j.hlc.2025.08.003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial fibrillation in patients with obesity: How can we optimize management?2026
  2. 22960-LB: Diabetes and Obesity as a Gateway to Atrial Fibrillation: Incidence, Burden, and Predictors among Eight Million Adults2026
  3. 3Abstract Fri149: The Growing Burden: Atrial Fibrillation Mortality Trends Among Obese Adults in the United States (1999–2023)2025
  4. 42959-LB: Temporal Sequencing of Heart Failure and Atrial Fibrillation in Patients with Obesity and Type 2 Diabetes: A Real-World Evidence Study2026
  5. 5Targeting the Cardiometabolic Axis: An Integrative Review on Therapeutic Advances2026