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July 12, 2026International Journal of Angiology

Document lists editorial board members for the International Journal of Angiology and contains no clinical data.

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Why the study?

Do anti-obesity pharmacotherapies like semaglutide and tirzepatide improve cardiovascular outcomes and symptoms in patients with obesity and cardiovascular disease?

Population

Patients with obesity and cardiovascular disease, including coronary heart disease, atrial fibrillation…

Design

Review

Key result

This document is a list of editorial board members for the International Journal of Angiology and contains no clinical trial data.

Authors

PDPaul DuruVTVasiliki Tasouli-DrakouNRNoyan Ramazani

Discussion

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Overview

Supports semaglutide and tirzepatide in obese CVD patients; extends trial data on weight-independent benefits.

Key Points

  • This review aims to evaluate the relationship between obesity and cardiovascular disease (CVD), focusing on therapeutic interventions.
  • Synthesized findings from clinical trials, systematic reviews, and narrative reviews.
  • Assessed key outcomes including heart failure symptoms, echocardiographic parameters, and inflammation biomarkers.
  • Evaluated the effects of anti-obesity agents like semaglutide and tirzepatide.
  • Obesity linked to increased risk of coronary heart disease, atrial fibrillation, stroke, and heart failure with preserved ejection fraction.
  • Semaglutide and tirzepatide showed significant weight reduction and improved functional capacity, as well as reduced inflammation independent of weight loss.
  • Patients with atrial fibrillation and obesity experienced greater improvements with semaglutide compared to those without atrial fibrillation.

Structured PICO

Do anti-obesity pharmacotherapies like semaglutide and tirzepatide improve cardiovascular outcomes and symptoms in patients with obesity and cardiovascular disease?

P
Population
Patients with obesity and cardiovascular disease, including coronary heart disease, atrial fibrillation, stroke, and heart failure with preserved ejection fraction (HFpEF)
I
Intervention
Anti-obesity pharmacotherapies (semaglutide, tirzepatide, and other agents)
O
Outcome
Heart failure symptoms, echocardiographic parameters, incidence of atrial fibrillation, inflammation biomarkers, and overall cardiovascular morbidity and mortality

Anti-obesity pharmacotherapies represent a disease-modifying approach for obesity-related cardiovascular conditions, particularly HFpEF and AF.

Limitations

  • Heterogeneity in evidence regarding the obesity paradox
  • Confounding by differences in cardiorespiratory fitness and lead time biases

Cite This Study

Duru et al. (2026) reported an editorial. This document is a list of editorial board members for the International Journal of Angiology and contains no clinical trial data.

synapsesocial.com/papers/6a532f464f7abc118aded033https://doi.org/10.1055/a-2904-8884
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