September 10, 2025Frontiers in ImmunologyOpen Access

HIV-associated depression: a translational framework targeting neuroimmune inflammation and psychosocial stress modulation

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The proposed framework aims to improve clinical outcomes for individuals with HIV-associated depression through targeted interventions.
Key pathological processes include microglial activation and neuroinflammation, leading to cognitive impairment and mood disorders.
Pharmacological targeting encompasses SSRIs and anti-inflammatory agents, optimized alongside ART regimens and psychosocial support.
Further research is needed to explore personalized treatment options and establish the long-term efficacy of these intervention strategies.

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A translational framework targeting neuroimmune inflammation and psychosocial stressors, suggesting potential clinically integrated interventions.

Yu et al. (2025) studied this question.

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A translational framework targeting neuroimmune inflammation and psychosocial stressors, suggesting potential clinically integrated interventions.