September 10, 2025Academic Emergency MedicineOpen Access

Intravenous Thrombolysis for Minor Acute Ischemic Stroke

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Discussion

Systematic review shows thrombolysis worsens mortality and independence in minor stroke patients, suggesting caution.

Thrombolysis increased mortality and reduced functional independence for patients with minor acute ischemic stroke.
The systematic review reported no significant improvement in excellent recovery with thrombolysis (OR: 0.85) in these patients.
Data were compiled from 4 trials (3364 patients) focusing specifically on minor acute ischemic stroke outcomes and safety.
High heterogeneity in trial designs and definitions raises concerns about the robustness of the findings.

Long et al. (2025) studied this question.

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