July 19, 2025Neurology

Meta-Analysis of Randomized Controlled Trials on IV Thrombolysis in Patients With Minor Acute Ischemic Stroke

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Authors

MDMohamed Fahmy DoheimUniversity of Pittsburgh TNThanh N. NguyenBoston University YXYunyun XiongCapital Medical University

Discussion

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Implication

Meta-analysis demonstrates IV thrombolysis is less effective for functional recovery in minor stroke patients, suggesting caution compared to standard care.

Key Points

IV thrombolysis did not show significant improvement in excellent functional recovery at 90 days compared to nonthrombolytic standard of care.
Patients receiving IV thrombolysis had lower odds of functional independence and higher odds of sICH and 90-day mortality.
The primary analysis included 4 randomized controlled trials with 3,364 minor stroke patients, focusing on NIHSS scores ≤5.
Findings indicate that IV thrombolysis may not offer better outcomes for minor stroke patients, highlighting the need for further research on mildly disabling symptoms.

Cite This Study

Doheim et al. (2025) studied this question.

synapsesocial.com/papers/689a02c9e6551bb0af8ccf30 https://doi.org/10.1212/wnl.0000000000213863

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Implication

Meta-analysis demonstrates IV thrombolysis is less effective for functional recovery in minor stroke patients, suggesting caution compared to standard care.

Meta-Analysis of Randomized Controlled Trials on IV Thrombolysis in Patients With Minor Acute Ischemic Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Meta-Analysis of Randomized Controlled Trials on IV Thrombolysis in Patients With Minor Acute Ischemic Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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