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September 10, 2025Journal of Evidence-Based Integrative MedicineOpen Access

Mechanisms of the Ershiwuwei Guijiu Pill in Treating Postmenopausal Osteoporosis Based on Network Analysis and Experimental Validation

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Authors

FDFengxia DuanLZLixue ZhangMNMuhammad Naveed

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Overview

Network analysis identifies targets in postmenopausal osteoporosis, suggesting potential signaling pathways for treatment.

Key Points

  • EWGP may improve bone metabolism through estrogen and calcium signaling pathways, enhancing health in postmenopausal women.
  • A total of 199 chemical substances were identified in EWGP, leading to the prediction of 419 targets and their relation to osteoporosis.
  • Molecular docking revealed active compounds like Protopine and significant targets such as the vitamin D receptor facilitate therapeutic effects.
  • Network pharmacology analysis combined with experimental validation showcases EWGP's potential multi-target approach in treating osteoporosis.

Cite This Study

Duan et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d647862cfhttps://doi.org/10.1177/2515690x251372707
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  5. 5Screening of ERβ‐Targeted Antipostmenopausal Osteoporosis Chemical Constituents From <scp> <i>Cornus officinalis</i> </scp> Based on Affinity Ultrafiltration and UHPLC‐Q‐Exactive Orbitrap MS2025