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November 30, 2025Biomedical Chromatography

Screening of ERβ‐Targeted Antipostmenopausal Osteoporosis Chemical Constituents From Cornus officinalis Based on Affinity Ultrafiltration and UHPLC‐Q‐Exactive Orbitrap MS

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Authors

YLYawen LiYLYishan LiKYKunping Yang

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Overview

Screening reveals potential therapy targets for postmenopausal osteoporosis from traditional Chinese medicine extracts.

Key Points

  • Active components in Cornus officinalis showed promising effects against postmenopausal osteoporosis, identified through molecular docking.
  • Molecular docking confirmed interactions of small molecule ligands with ERβ enzyme, targeting postmenopausal osteoporosis.
  • Analysis utilized UHPLC-Q-Exactive Orbitrap MS to identify 17 active components, including sweroside and cornuside.
  • Traditional Chinese medicine screening methods may enhance quality control and therapeutic strategies for osteoporosis.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/692b9da91d383f2b2a37a618https://doi.org/10.1002/bmc.70270
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