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September 10, 2025

Electroacupuncture regulates blood glucose dysregulation by up-regulating IGF1-mediated PI3K/Akt signaling pathway in mice with circadian rhythm disorder.

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Authors

JMJiarui MiaoLiaoning University of Traditional Chinese MedicineFXFan XuChinese PLA General Hospital

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Implication

Observational analysis shows electroacupuncture lowers blood glucose in mice with circadian rhythm disorder, indicating PI3K/Akt signaling is involved.

Key Points

  • Electroacupuncture significantly reduces fasting plasma glucose in mice with circadian rhythm disorder, enhancing glucose metabolism.
  • Insulin resistance metrics, including HOMA-IR and serum insulin, improved substantially after electroacupuncture treatment (P<0.01).
  • Experimental model established through constant light exposure for four weeks emphasized the link between circadian disruption and metabolic dysregulation.
  • Inhibition of PI3K signaling blocked the beneficial effects of electroacupuncture on blood glucose levels, highlighting the pathway's role in treatment.

Cite This Study

Miao et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d647852f4https://doi.org/10.13702/j.1000-0607.20240183
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Electroacupuncture improves glucose and lipid metabolism disorders in diabetic obese rats via PI3K/Akt/GLUT4 pathway].2025 · 1 citations
  2. 2[Inhibitory effect of electroacupuncture on microglial activation via Notch1/Hes1 pathway in Parkinson's disease mice].2025
  3. 3Electroacupuncture modulates myocardial insulin signaling and inflammatory markers in a rat model of type 2 diabetes2025 · 1 citations
  4. 4[Mechanism of electroacupuncture in improving obesity with insulin resistance by regulating the balance of Th17 and Treg cells through SIRT1].2025
  5. 5[Effects of electroacupuncture on cognitive impairment and mitophagy mediated by KIF5A/Miro1 pathway in Parkinson's disease mice].2025 · 1 citations