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September 10, 2025

Additive Effects of Photobiomodulation and Adipose-Derived Stem Cells on Stereology, Macrophage Polarization, and Growth Factor Expression in the Inflammatory and Proliferative Phases of Type 2 Diabetic Wound Healing in Rats.

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Authors

AMAli MoradiAAAbdollah AminiAMAtarodalsadat Mostafavinia

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Overview

Experimental evaluation shows combined PBM and ADS enhance macrophage polarization and growth factors in diabetic wound healing.

Key Points

  • The combination of photobiomodulation and adipose-derived stem cells greatly improved wound healing outcomes in diabetic rats.
  • Significant reductions in neutrophil and M1 macrophage counts were observed with PBM+ADS, indicating less inflammation.
  • Fibroblast and M2 macrophage counts increased substantially with treatment, especially with the PBM+ADS combination.
  • This study suggests that combining PBM and ADS could provide a powerful approach to enhance healing in diabetic wounds.

Cite This Study

Moradi et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d6478504ehttps://doi.org/10.1177/15578550251363062
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Promoting of Biomechanics' Properties Incisional Wound Repair by Mesenchymal Stem Cell Transplantation.2025
  2. 2Mesenchymal stem cell-conditioned medium accelerates type 2 diabetic wound healing by targeting TNF and chemokine signaling2025
  3. 3Effect of rhGM-CSF in promoting wound healing via macrophage immunomodulation2025 · 3 citations
  4. 4Three‐Dimensional Influence of Photobiomodulation on Adipose‐Derived Stem Cell Behavior2025
  5. 5Correction of regulatory molecules expression at the inflammation stage using photobiomodulation therapy in chronic wound modeling2025