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September 10, 2025Open Access

Impact of Tuberculosis Preventive Treatment on Adverse Pregnancy Outcomes in women living with HIV in Uganda: A Quasi-experimental study using routine care data

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Authors

JMJoseph MusaaziInfectious Disease Research InstituteCSChristine Sekaggya‐WiltshireMulago HospitalSZStella Zawedde‐Muyanja

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Implication

Quasi-experimental study finds no significant link between tuberculosis preventive treatment and adverse pregnancy outcomes in HIV-positive women in Uganda.

Key Points

  • No significant association was found between tuberculosis preventive treatment and adverse pregnancy outcomes.
  • Only 10% of pregnant women living with HIV experienced adverse outcomes, with similar rates in treated and untreated groups.
  • The study analyzed routine care data from 521 women on antiretroviral therapy in Uganda, highlighting safety during pregnancy.
  • Strengthening data collection is vital for maternal and neonatal health as tuberculosis preventive treatment expands in high-burden regions.

Cite This Study

Musaazi et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d647846d8https://doi.org/10.21203/rs.3.rs-7170241/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Maternal, Pregnancy, and Infant Outcomes in Women Treated for Multidrug-Resistant/Rifampicin-Resistant Tuberculosis With Novel and Repurposed Drugs in KwaZulu-Natal, South Africa2025 · 1 citations
  2. 2Effectiveness of tuberculosis preventive treatment on disease incidence among people living with HIV/AIDS: A systematic review and meta-analysis2025 · 5 citations
  3. 3Pharmacokinetics of first-line tuberculosis drugs rifampin, isoniazid, ethambutol, and pyrazinamide during pregnancy and postpartum with and without efavirenz-based antiretroviral treatment: IMPAACT P1026s study2025
  4. 4HIV and Syphilis Coinfection in Pregnancy and Adverse Birth Outcomes in Uganda2025
  5. 5Tuberculosis in Pregnant Women After COVID-19: Features of Prevention, Diagnosis, and Treatment (Narrative Review)2025 · 1 citations