September 10, 2025AgingOpen Access

Lactobacillus amylovorus KU4 inhibits adipocyte senescence in aged mice through necdin regulation of p53 activity

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Observational analysis reveals LKU4 mitigates adipocyte senescence in aged mice, highlighting potential for metabolic disorder prevention.

Lactobacillus amylovorus KU4 administration significantly inhibits adipocyte senescence in 24-month-old mice.
LKU4 reduced expression of key senescence markers, including p53, while enhancing necdin levels.
Mechanistic studies indicate that necdin regulates p53 activity by blocking p53-p300 interactions.
Successful LKU4 intervention may suggest new therapeutic avenues for age-related metabolic disorders.

Yang et al. (2025) studied this question.

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Observational analysis reveals LKU4 mitigates adipocyte senescence in aged mice, highlighting potential for metabolic disorder prevention.