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September 10, 2025Stem Cell Reviews and ReportsOpen Access

Mitohormesis and Regeneration: Natural Compounds Chlorogenic Acid (CGA) and Isovanillic Acid 3-O-sulfate (IVAS) Boost Muscle Cell Recovery in the Equine Athlete Model

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Authors

OWOlga Witkowska‐PiłaszewiczMNMałgorzata Nowicka-KazmierczakPPPatrycja Pietrzak

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Overview

Observational analysis shows that chlorogenic acid and isovanillic acid improve muscle regeneration in horses, suggesting potential benefits for athletes.

Key Points

  • CGA improved muscle cell viability by 216-227% under normothermia and heat stress.
  • IVAS effectively improved cell recovery only without heat stress, indicating different mechanisms.
  • The Hybrid treatment maintained elongated muscle cell morphology and minimized total apoptosis post-stress.
  • Mitochondrial genes were significantly upregulated in the Hybrid group, highlighting its potential in recovery strategies.

Cite This Study

Witkowska‐Piłaszewicz et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d647831e6https://doi.org/10.1007/s12015-025-10959-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chlorogenic acid modulates mitochondrial damage and mitophagy to repair injured myocardial tissue and cells2025 · 4 citations
  2. 2<i>trans</i>-Resveratrol and Hesperidin Supplementation with Treadmill Exercise Alleviates Methylglyoxal-Induced Skeletal Muscle Dysfunction2025
  3. 3hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway2025 · 8 citations
  4. 4C60 fullerene promotes recovering rat musculus gastrocnemius contracting activity after neurogenic atrophy2025
  5. 5In Vitro Effects of Hyaluronic Acid on Equine Mesenchymal Stem Cells in Osteoarthritis Research2026