Recognition of molecular clusters and a novel prognostic signature based on natural killer cell-related genes in skin cutaneous melanoma

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A prognostic signature based on 32 NK cell-related genes was developed for improving outcomes in skin cutaneous melanoma (SKCM).
Different molecular clusters identified by NK cell-related genes showed significant differences in drug sensitivity and overall survival (Log-rank, p < 0.0001).
This research utilized multiple machine learning algorithms, yielding a 12-NKCRG optimal prognostic signature to aid therapeutic strategies.
Key genes CD247 and KIR2DL4 may serve as valuable prognostic biomarkers and potential therapeutic targets for SKCM patients.

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Analysis reveals molecular clusters and a novel prognostic signature based on natural killer cell genes in skin cutaneous melanoma.

Yuan et al. (2025) studied this question.

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