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September 10, 2025Open Access

Formulation and Evaluation of PVA-Stabilized Nanoemulsion Loaded with Methylsulfonylmethane for the Treatment of Experimentally Induced Arthritis

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Authors

SRSajid RazaMAMuhammad AkhlaqSASophia Awais

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Overview

This formulation improves transdermal delivery and sustained release in arthritis management, suggesting promising outcomes.

Key Points

  • The PVA-stabilized nanoemulsion with MSM shows notable improvements in transdermal delivery for arthritis treatment.
  • An encapsulation efficiency of 92.5% was achieved, reflecting the formulation's high drug-loading capacity.
  • In vivo studies on arthritis models demonstrated significant reductions in paw swelling and inflammation, comparable to diclofenac.
  • The developed nanoemulsion maintains stability for over 90 days, indicating its potential as a viable drug delivery system.

Cite This Study

Raza et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d647821aahttps://doi.org/10.20944/preprints202509.0284.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Formulation development and optimization of nanoemulsion gel containing Prosopis cineraria, Aerva javanica, and Fagonia indica extracts for treatment of arthritis2025 · 2 citations
  2. 2Preclinical Evaluation of Nanoemulsion and Polymeric Nanocapsule Delivery Systems of 4-(Phenylselanyl)-2H-Chromen-2-One for Rheumatoid Arthritis and Comorbidities2025
  3. 3Preparation and Characterization of Transdermal Patches for the treatment of Arthritis2025
  4. 4Exploring Micellar Systems for Intra-Articular Delivery of Vanillic Acid in Management of Osteoarthritis.2025
  5. 5Mechanobiologically Engineered Mimicry of Extracellular Vesicles for Improved Systemic Biodistribution and Anti-Inflammatory Treatment Efficacy in Rheumatoid Arthritis.2025