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September 5, 2025Frontiers in MicrobiomesOpen Access

The microbiome and lung cancer: microbial effects on host immune responses and treatment outcomes

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Authors

ABAlexis BaileyKLKerstin K. LeutherLRLary A. Robinson

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Overview

This review highlights how microbiome influences immune responses and treatment outcomes in lung cancer, suggesting therapeutic interventions.

Key Points

  • Alterations in the microbiome significantly influence immune responses and treatment effectiveness in lung cancer.
  • Emerging evidence indicates that specific microbial species can enhance or suppress T-cells and other immune cells in relation to lung cancer.
  • This review encompasses insights from preclinical and clinical studies, emphasizing the gut-lung axis in understanding lung cancer progression.
  • Microbiome-targeted therapies such as probiotics and antibiotics show potential in improving lung cancer treatment outcomes.

Cite This Study

Bailey et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477e4dfhttps://doi.org/10.3389/frmbi.2025.1606551
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The emerging role of microbiota in lung cancer: a new perspective on lung cancer development and treatment2025 · 12 citations
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  3. 3Respiratory microbiome-host interaction on lung carcinogenesis, immunity, and immunotherapy2025 · 3 citations
  4. 4Dissecting the intratumoral microbiome landscape in lung cancer2025 · 11 citations
  5. 5Role of gut microbiota in cancer modulation: molecular mechanisms and emerging therapeutic strategies2026 · 1 citations