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September 10, 2025Neuro-OncologyOpen Access

PROTOCOL FOR A PROSPECTIVE, SINGLE-ARM, PHASE II CLINICAL TRIAL EVALUATING THE EffiCACY AND SAFETY OF NEO-ADJUVANT STEREOTACTIC RADIOSURGERY PRIOR TO SURGICAL RESECTION OF A DOMINANT BRAIN METASTASIS

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Authors

HRHamoun RozatiRLRachel LewisJCJohn Conibear

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Overview

This single-arm trial evaluates local event-free survival in patients with brain metastases, indicating the potential of innovative pre-surgical therapies.

Key Points

  • The trial aims to improve local event-free survival in patients undergoing surgery for brain metastases.
  • Primary endpoints include time to local event-free survival, symptomatic radionecrosis, and focal leptomeningeal disease.
  • This is a prospective, single-arm phase II clinical trial open to multiple centers offering stereotactic radiosurgery.
  • Findings may establish the role of neo-adjuvant stereotactic radiosurgery in improving patient outcomes.

Cite This Study

Rozati et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d647814dehttps://doi.org/10.1093/neuonc/noaf185.079
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neoadjuvant Stereotactic Radiosurgery for Brain Metastases: A Systematic Review and Meta-Analysis2025
  2. 2Neoadjuvant stereotactic radiosurgery for brain metastases: Current evidence and clinical perspectives.2025
  3. 3Neoadjuvant stereotactic radiotherapy for brain metastasis: a review of ongoing clinical trials2025
  4. 4Preliminary Results of Two-Stage Radiosurgery for Brain Metastases2025
  5. 5MMAP-15 SURGICAL RESECTION RESULTS IN IMPROVED SEIZURE OUTCOMES IN EPILEPTOGENIC BRAIN METASTASES COMPARED TO RADIOSURGERY ALONE2025