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August 15, 2025Neuro-Oncology Practice

Neoadjuvant Stereotactic Radiosurgery for Brain Metastases: A Systematic Review and Meta-Analysis

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Authors

BHBardia HajikarimlooMHMohammad Amin HabibiIMIbrahim Mohammadzadeh

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Overview

Systematic review shows neoadjuvant stereotactic radiosurgery improves local control in brain metastasis, suggesting low toxicity.

Key Points

  • Neoadjuvant stereotactic radiosurgery significantly improves local control rates at 12 months, reaching 91%.
  • Pooled distant brain failure rates were 35% at 12 months, indicating notable concerns in management.
  • Systematic review included ten studies assessing key outcomes in 791 patients, showcasing the efficacy of neoadjuvant therapy.
  • Neoadjuvant SRS may offer beneficial results compared to traditional methods, calling for further randomized trials.

Cite This Study

Hajikarimloo et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d6477216fhttps://doi.org/10.1093/nop/npaf086
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neoadjuvant stereotactic radiosurgery for brain metastases: Current evidence and clinical perspectives.2025
  2. 2Neoadjuvant stereotactic radiotherapy for brain metastasis: a review of ongoing clinical trials2025
  3. 3PROTOCOL FOR A PROSPECTIVE, SINGLE-ARM, PHASE II CLINICAL TRIAL EVALUATING THE EffiCACY AND SAFETY OF NEO-ADJUVANT STEREOTACTIC RADIOSURGERY PRIOR TO SURGICAL RESECTION OF A DOMINANT BRAIN METASTASIS2025
  4. 4Hypo-Fractionated Stereotactic Radiosurgery for the Management of Brain Metastases2025 · 3 citations
  5. 5P11.30.A IMMUNOMODULATORY EFFECTS OF PREOPERATIVE STEREOTACTIC RADIOSURGERY IN BRAIN METASTASES: PROSPECTIVE INTEGRATION OF TISSUE AND CEREBROSPINAL FLUID PROFILING2025