September 10, 2025VaccinesOpen Access

Systemic and Mucosal Immune Responses Induced by Adenoviral-Vectored Consensus H5 Influenza A Vaccines in Mice and Swine

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All vaccine strategies induced significant anti-H5 immunity, with a notable effectiveness showcased in both mice and swine.
Ad5/Ad6 IM immunization produced strong systemic IgG and microneutralization titers while IN delivery enhanced mucosal IgA levels.
Comparative analysis showed that the Ad28/Ad48 vaccines induced similar immunity patterns but to a lesser degree than the Ad5/Ad6 strategy.
Adenoviral-vectored H5CC vaccines demonstrated broad, cross-clade immunity, particularly supporting systemic responses from IM vaccination.

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This study evaluates immune responses from adenoviral-vectored H5 influenza vaccines in mice and swine, indicating route-dependent efficacy.

Madapong et al. (2025) studied this question.

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This study evaluates immune responses from adenoviral-vectored H5 influenza vaccines in mice and swine, indicating route-dependent efficacy.