Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025MedicineOpen Access

Decoding rheumatoid arthritis: Biomarker identification and immune profiling via bioinformatics and Mendelian randomization

View Full Paper
Ask AI
Bookmark
Share

Authors

SSShoujia ShaoWZWenxing ZengJZJingtao Zhang

Discussion

Loading...

Member takes

Overview

This research reveals key biomarkers and immune pathways in rheumatoid arthritis, indicating potential therapeutic targets.

Key Points

  • The study identifies 13 critical genes related to rheumatoid arthritis susceptibility, improving diagnostic strategies.
  • Using data from gene expression databases, pivotal gene expression with eQTLs was analyzed to find disease associations.
  • Comprehensive analyses, including gene ontology and enrichment analysis, validated the roles of identified biomarkers.
  • The findings highlight the significant contributions of immune cells, particularly M2 macrophages and CD8+ T cells, in RA.

Cite This Study

Shao et al. (2025) studied this question.

synapsesocial.com/papers/68c23a74b210217d64780cf4https://doi.org/10.1097/md.0000000000043872
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genome‐Wide Association Analysis and Multi‐Omic Mendelian Randomization Insight Into the Molecular Network of Immune‐Related Dysfunction in the Pathogenesis of Rheumatoid Arthritis2025
  2. 2Mendelian randomization identifies multiple immune cell surface markers as potential causal contributors and drug targets in rheumatoid arthritis2026
  3. 3Bioinformatics Analysis Screened and Identified Key Genes, miRNAs and TFs as Potential Biomarkers for Progression of Rheumatoid Arthritis2025
  4. 4Identification of potential biomarkers in Rheumatoid Arthritis based on DNA methylation and scRNA-Seq2025
  5. 5Integrative molecular network analysis of genetic risk factors to infer biomarkers and therapeutic targets for rheumatoid arthritis2025