Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 3, 2025Current Bioinformatics

Identification of potential biomarkers in Rheumatoid Arthritis based on DNA methylation and scRNA-Seq

View Full Paper
Ask AI
Bookmark
Share

Authors

THTieying HouGFGuo-Liang FanYLYang Liu

Discussion

Loading...

Member takes

Overview

This analysis uncovers diagnostic potential of TNFSF10 in rheumatoid arthritis patients, highlighting immune cell interactions.

Key Points

  • The study identified four key genes, with TNFSF10 showing significant diagnostic ability in RA.
  • TNFSF10 demonstrated an AUC value greater than 0.9 in both training and validation sets for RA diagnostics.
  • These findings suggest TNFSF10 may be a promising target for further therapeutic exploration in RA.
  • Analysis revealed elevated interactions of CD8+ T cells with other immune cells, indicating complex immune dynamics in RA.

Cite This Study

Hou et al. (2025) studied this question.

synapsesocial.com/papers/68e02f3cf0e39f13e7fa27b3https://doi.org/10.2174/0115748936311856250906073058
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1limma powers differential expression analyses for RNA-sequencing and microarray studies2015 · 44,501 citations