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September 5, 2025BioengineeringOpen Access

In Vivo Targeted Reprogramming of Cardiac Fibroblasts for Heart Regeneration: Advances and Therapeutic Potential

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Authors

WAWaqas AhmadSDSuchandrima DuttaXHXingyu He

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Overview

This review highlights advances in heart regeneration by converting cardiac fibroblasts, emphasizing reprogramming methods and delivery systems.

Key Points

  • In vivo targeted reprogramming of cardiac fibroblasts effectively promotes heart regeneration and reduces fibrosis.
  • The study discusses advancements in delivery systems that optimize the precision of reprogramming factors for cardiac cells.
  • Challenges remain in achieving high reprogramming efficiency and avoiding off-target effects in non-fibroblast cardiac cells.
  • Understanding fibroblast heterogeneity and transcriptional drivers is crucial for developing effective anti-fibrotic therapies.

Cite This Study

Ahmad et al. (2025) studied this question.

synapsesocial.com/papers/68c23a74b210217d647809e8https://doi.org/10.3390/bioengineering12090940
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  1. 1Rewiring the scar: translational advances in cardiac fibrosis.2025 · 4 citations
  2. 2Heart Regeneration and Repair: Molecular Mechanism and Therapeutic Targets2025 · 6 citations
  3. 3Refining fibroblast-to-cardiomyocyte transdifferentiation protocols to explore emergent self- organization in cardiac cultures2025
  4. 4Intercellular Targetable Mechanistic Interface for Cardiac Fibrosis2026
  5. 5Transcriptome fingerprinting of aberrant fibroblast activation unlocks effective therapeutics to tackle cardiac fibrosis2025 · 3 citations