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September 5, 2025Clinical Endocrinology

Temporal Variation of Biochemical Markers and Adenoma Predictors in Normocalcemic Primary Hyperparathyroidism: A Multicenter Retrospective Analysis

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Authors

BABerçem AyçiçekMTMazhar Müslüm TunaİEİsmail Engin

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Overview

Multicenter retrospective analysis illuminates temporal variations and diagnostic performance of biomarkers in nPHPT.

Key Points

  • Higher PTH levels and normal range calcium indicate parathyroid adenoma in normocalcemic patients.
  • Logistic regression revealed PTH showed the highest diagnostic accuracy (AUC = 0.91) for adenoma localization.
  • Temporal evaluations showed significant declines in serum calcium and PTH, along with increased urinary calcium excretion.
  • Comprehensive analysis of 474 patients provided insights into dynamic nature and predictors of nPHPT.

Cite This Study

Ayçiçek et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477f927https://doi.org/10.1111/cen.70024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A-075 Distinguishing Secondary Hyperparathyroidism from Early Normocalcemic Primary Hyperparathyroidism: Does Selection of Reference Change Values Change the Clinical Significance of Diagnostic Outcomes?2025
  2. 2Clinicopathological insights into primary hyperparathyroidism: a comprehensive single-center retrospective study.2025
  3. 3Factors Associated With Successful Parathyroid Adenoma Localisation in Sestamibi Study-Can Change in Serum Calcium Be a Useful Indicator?2025
  4. 4Receptor gene expressions and their association with biochemical parameters in primary hyperparathyroidism patients2025
  5. 5Clinical significance of chloride-to-phosphorus and chloride-to-magnesium ratios in primary hyperparathyroidism2025