Dynamic Relevance Between Reflux Events and Esophageal Motility in Patients With Proton Pump Inhibitor‐Refractory Gastroesophageal Reflux Disease

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Discussion

Observational study identifies significance of reflux events and esophageal motility in GERD patients, suggesting potential treatment targets.

Patients with proton pump inhibitor-refractory GERD experienced longer acid reflux episodes than those responsive to treatment.
The number of long acid reflux episodes was notably higher in the PPI-refractory group, indicating severe esophageal motility issues.
Observational analysis using pH-impedance-pressure monitoring assessed reflux symptoms and motility in patients over 24 hours.
Findings highlight the need for alternative therapies, as ineffective peristalsis may contribute to persistent reflux symptoms.

Lin et al. (2025) studied this question.

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Observational study identifies significance of reflux events and esophageal motility in GERD patients, suggesting potential treatment targets.