Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025EJNMMI ResearchOpen Access

Imaging renal mitochondrial dysfunction in chronic kidney disease: a repurposed role for 99mTcTc-MIBI SPECT/CT

View Full Paper
Ask AI
Bookmark
Share

Authors

SPS. ParkCLChae Hong LimSJSo‐Young Jin

Discussion

Loading...

Member takes

Overview

[99mTc]Tc-MIBI identifies mitochondrial dysfunction in chronic kidney disease, correlating uptake with renal health.

Key Points

  • CKD patients exhibited significantly lower renal [99mTc]Tc-MIBI uptake percentage compared to healthy volunteers.
  • Mean SUV was positively correlated with renal mitochondrial content in CKD patients, indicating potential diagnostic value.
  • AUC for mean SUV as a predictor of CKD was 0.886, showcasing high diagnostic accuracy compared to conventional biomarkers.
  • [99mTc]Tc-MIBI SPECT/CT serves as an effective noninvasive imaging biomarker for assessing renal mitochondrial dysfunction.

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477f70bhttps://doi.org/10.1186/s13550-025-01306-7
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quantitative Susceptibility Mapping for Evaluating Renal Functional Injury in Chronic Kidney Disease Patients: A Pilot Study2025 · 2 citations
  2. 2SNMMI/EANM/ACNM Procedure Standard/Procedure Guideline on the Use of Molecular Imaging for Renal Mass Characterization2025
  3. 3Multiparametric MRI for Early Chronic Kidney Disease Detection: Insights Into Renal Microcirculation2026
  4. 4Dynamic Acquisition of [ <sup>99m</sup> Tc]Tc-Pyrophosphate SPECT/CT Images in Transthyretin Cardiac Amyloidosis: A Pilot Study2025
  5. 5Progress of functional magnetic resonance imaging in the assessment of transplanted kidney function2025 · 1 citations