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September 5, 2025Frontiers in OncologyOpen Access

Correlation between MGMT methylation and the efficacy of bevacizumab in high-grade glioma

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Authors

CYChengrui YanXBXuexue BaiCWChao Wu

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Overview

Investigating the association of MGMT methylation with survival outcomes in patients treated with bevacizumab.

Key Points

  • Methylated MGMT status significantly improves overall survival and progression-free survival after bevacizumab treatment.
  • Among 57 patients, the methylated MGMT group showed higher tumor control rates compared to the unmethylated group.
  • Patients experienced reduced steroid dosages and improved KPS scores following bevacizumab treatment.
  • Multivariate analysis identified radiotherapy and complete resection as key factors affecting survival in high-grade glioma.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477f4bdhttps://doi.org/10.3389/fonc.2025.1644934
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation between MGMT methylation and the efficacy of bevacizumab in high-grade glioma2025
  2. 2Predictive role of MGMT and IDH status in the efficacy of bevacizumab for high-grade glioma: a retrospective study2025
  3. 3P05.16.B DEFINING THE OPTIMAL MGMT METHYLATION CUTOFF AND ITS CORRELATION WITH SIGNIFICANT GENETIC ALTERATIONS2025
  4. 4The role of extent of resection, chemoradiation, and MGMT promoter methylation in overall survival in a large cohort of IDH-wildtype glioblastoma2025 · 4 citations
  5. 5Bevacizumab alternating chemotherapy for improving the survival of patients with recurrent high-grade glioma2025