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September 10, 2025Neurosurgical FOCUSOpen Access

The role of extent of resection, chemoradiation, and MGMT promoter methylation in overall survival in a large cohort of IDH-wildtype glioblastoma

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Authors

MPMegan ParkerACAustin CarmichaelASAntolin Serrano-Farias

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Overview

Observational analysis shows that MGMT promoter methylation and extent of resection improve survival in glioblastoma, suggesting implications for treatment planning.

Key Points

  • Maximizing the extent of resection notably improves overall survival in glioblastoma patients.
  • In multivariate analysis, gross-total resection is associated with a 40% improvement in survival compared to excisional biopsy.
  • Chemotherapy and MGMT promoter methylation both independently enhance survival rates among individuals with glioblastoma.
  • The influence of gross-total resection on survival in MGMT methylated tumors receiving chemoradiation requires further research.

Cite This Study

Parker et al. (2025) studied this question.

synapsesocial.com/papers/68c23f63b210217d64796aechttps://doi.org/10.3171/2025.5.focus25350
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IDH wild-type glioblastoma: Predictive value of standard-of-care (SOC) MRI for establishing MGMT promoter methylation status2025 · 1 citations
  2. 2P05.16.B DEFINING THE OPTIMAL MGMT METHYLATION CUTOFF AND ITS CORRELATION WITH SIGNIFICANT GENETIC ALTERATIONS2025
  3. 3P05.06.B CLINICAL USEFULNESS OF MGMT PROMOTER METHYLATION QUANTIFICATION IN GBM PATIENTS TREATED WITH CHEMO-RADIATION THERAPY2025
  4. 4MOLECULAR MARKERS IN PREDICTING THE OUTCOME OF DIFFUSE GLIOMA GRADE 4 TREATMENT2025
  5. 5Predictive role of MGMT and IDH status in the efficacy of bevacizumab for high-grade glioma: a retrospective study2025