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August 15, 2025BiomedicinesOpen Access

Cytokine Networks in Triple-Negative Breast Cancer: Mechanisms, Therapeutic Targets, and Emerging Strategies

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Authors

MRMaría Rosado-SanzNMNúria Martínez-AlarcónAAAdrián Abellán-Soriano

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Overview

This review discusses cytokines' role in tumor progression and emerging therapeutic strategies targeting TNBC.

Key Points

  • Cytokine networks play a crucial role in the biology of triple-negative breast cancer, influencing processes like immunomodulation.
  • The review highlights key mechanisms such as angiogenesis and epithelial–mesenchymal transition associated with TNBC.
  • Emerging therapeutic strategies include monoclonal antibodies and CAR-T cell approaches directed at cytokines.
  • These findings may guide new targeted therapies for patients with triple-negative breast cancer, addressing unmet needs.

Cite This Study

Rosado-Sanz et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64772124https://doi.org/10.3390/biomedicines13081945
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Tumor Microenvironment in Triple-Negative Breast Cancer and Its Therapeutic Targeting2025
  2. 2Therapeutic innovations in triple negative breast cancer: integrating molecular targeting and monoclonal antibody strategies2025 · 5 citations
  3. 3Integrating molecular targeting and immune modulation in triple-negative breast cancer: from mechanistic insights to therapeutic innovation2025 · 5 citations
  4. 4Inflammation-associated drug resistance and tumor growth in TNBC2025 · 10 citations
  5. 5Triple-Negative Breast Cancer: Molecular Subtypes, Therapeutic Challenges, and Emerging Strategies—A Systematic Review2025