September 5, 2025ESMO OpenOpen Access

Early-onset colorectal cancer patients exhibit a distinct molecular fingerprint: insights from a large-scale NGS study of 1209 patients

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Patients with early-onset colorectal cancer exhibit a unique genomic profile, leading to poorer overall survival than average-onset patients.
In a cohort of 1209 metastatic CRC patients, EO-CRC was associated with higher incidences of specific genetic amplifications and mutations.
The study utilized next-generation sequencing to analyze genomic alterations and overall survival outcomes in different patient groups.
Observations highlight the need for personalized treatment strategies tailored to the distinct molecular profiles of early-onset colorectal cancer.

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Retrospective analysis shows unique genomic alterations in early-onset colorectal cancer patients, suggesting distinct clinical characteristics.

Pretta et al. (2025) studied this question.

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Retrospective analysis shows unique genomic alterations in early-onset colorectal cancer patients, suggesting distinct clinical characteristics.