September 10, 2025Cancer ControlOpen Access

Differential Analysis of Early-Onset and Late-Onset Colorectal Cancer Based on Multidimensional Evidence Integration: A Review

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Early-onset colorectal cancer is often diagnosed at an advanced stage with more severe symptoms.
The PIK3CA mutation and TP53 deletion display higher rates in early-onset colorectal cancer than in late-onset type.
Differences in transcriptomics and metabolomics profiles may explain the distinct biological characteristics of both types.
There's ongoing debate about the prognosis of early-onset colorectal cancer, which varies by age, gender, and ethnicity.

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Review analyzes clinical manifestations and molecular mechanisms in early-onset vs. late-onset colorectal cancer.

Mi et al. (2025) studied this question.

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