September 5, 2025BMC CancerOpen Access

Detection and natural history of HPV infection of oral cavity and tonsils – a systematic literature review

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Discussion

Systematic review reveals oral HPV prevalence in general population and PLWH, highlighting vaccination impact.

Oral HPV infection prevalence ranges from 0.67 to 11.89%, with higher rates observed in males.
Individuals living with HIV showed oral HPV prevalence rates between 2% and 40%, indicating significant risk.
Vaccination of adolescents prevents oral HPV infection, which is crucial to reduce oropharyngeal cancer incidence.
Further research on oral HPV persistence and optimal sampling methods remains essential for better understanding.

Maltseva et al. (2025) studied this question.

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