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September 5, 2025MicroorganismsOpen Access

An AI-Designed Antibody-Engineered Probiotic Therapy Targeting Urease to Combat Helicobacter pylori Infection in Mice

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Authors

FZFeiliang ZhongXLXintong LiuXWXuefang Wang

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Overview

This research demonstrates improved urease inhibition and reduced Hp colonization in mice, suggesting a new probiotic strategy against antibiotic resistance.

Key Points

  • The I107W mutant antibody achieved 65.6% urease inhibition, indicating a significant improvement in activity over the wild-type antibody.
  • Treatment with engineered E. coli Nissle 1917 led to a 4.42 log10 CFU reduction in gastric Helicobacter pylori colonization, confirming its effectiveness.
  • Machine learning-guided antibody optimization prioritized mutational hotspots to enhance antibody performance in targeting urease.
  • Histopathological analysis showed enhanced mucosal repair in mice treated with the I107W antibody, indicating its potential benefits.

Cite This Study

Zhong et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477d764https://doi.org/10.3390/microorganisms13092043
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