September 5, 2025Open Access

Genetic overlap and shared risk loci between autism spectrum disorder and cardiometabolic traits

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Authors

GMGerard MuntanéUniversitat Pompeu Fabra OAOle A. AndreassenOslo University Hospital ASAlexey ShadrinOslo University Hospital

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Implication

This observational analysis reveals shared genetic loci between autism spectrum disorder and cardiometabolic traits, suggesting implications for treatment.

Key Points

Significant polygenic overlap exists between autism spectrum disorder and cardiometabolic traits, which may influence treatment approaches.
A total of 100 shared genetic loci were identified, linking 124 genes to both autism spectrum disorder and metabolic conditions.
Using genome-wide association studies, small positive and negative genetic correlations were revealed between autism and various cardiometabolic traits.
Findings indicate that shared genetic factors could lead to more targeted interventions for managing autism spectrum disorder and related cardiometabolic health issues.

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Muntané et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477cf12 https://doi.org/10.21203/rs.3.rs-7130451/v1

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Implication

This observational analysis reveals shared genetic loci between autism spectrum disorder and cardiometabolic traits, suggesting implications for treatment.

Genetic overlap and shared risk loci between autism spectrum disorder and cardiometabolic traits

Discussion

Member takes

Implication

Key Points

Cite This Study

Genetic overlap and shared risk loci between autism spectrum disorder and cardiometabolic traits

Discussion

Member takes

Implication

Key Points

Cite This Study

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