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September 5, 2025Current Gene Therapy

Role of Exosomal miRNAs and Epigenetic Modifications in Diabetic Nephropathy: Insights into Novel Diagnostic and Therapeutic Strategies

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Authors

SNSrinivas NagaramASAniruddha SenVSVijay Singh

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Overview

This review examines exosomal miRNAs and epigenetic modifications in diabetic nephropathy, suggesting potential diagnostic and therapeutic strategies.

Key Points

  • Exosomal miRNAs serve as promising early biomarkers for diabetic nephropathy, aiding in disease identification and monitoring.
  • Significant epigenetic modifications, including DNA methylation and histone alteration, play a critical role in diabetic nephropathy progression.
  • The interplay between exosomal miRNAs and epigenetic changes influences inflammatory pathways, such as IL-6 and NF-κB.
  • Improved detection techniques for miRNAs and exosomal isolation are essential for clinical translation and effective patient management.

Cite This Study

Nagaram et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477ca65https://doi.org/10.2174/0115665232376803250815065514
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in the Epigenetic Mechanisms of Diabetic Nephropathy Pathogenesis2025
  2. 2Exploring the Proteomic Signature of Diabetic Nephropathy: Implications for Early Diagnosis and Treatment2025 · 4 citations
  3. 3Comprehensive bioinformatics and in vivo validation reveal key molecular drivers of diabetic nephropathy progression2025 · 2 citations
  4. 4Identification and experimental validation of demethylation-related genes in diabetic nephropathy2025
  5. 5Serum Levels of MicroRNA-210 as a Pathogenic Factor in Patients with Diabetes and Diabetic Nephropathy: A Cross-sectional Study2025