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September 5, 2025AAP Grand Rounds

Caffeine Does Not Reduce Hospital Stay for Preterm Infants

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Overview

Randomized controlled trial assessed caffeine's effect on hospital stay in moderately preterm infants, suggesting no reduction.

Key Points

  • Prolonged caffeine use did not significantly reduce hospital stay for moderately preterm infants.
  • Median days to hospital discharge were similar: 18.0 for caffeine vs. 16.5 for placebo, with P >0.99.
  • The study used a randomized controlled trial approach across 29 NICUs with 827 infants enrolled.
  • Caffeine reduced apnea-free duration but did not affect overall length of stay or outpatient visit rates.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68c23966b210217d6477c162https://doi.org/10.1542/gr.54-3-29
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Caffeine Was Associated With Shorter Continuous Positive Airway Pressure Treatment for Infants up to Eight Weeks Old Hospitalised for Bronchiolitis2025
  2. 2High Vs Low Dose Caffeine in Management of Apnea of Prematurity: A Single-Center Observational Study2025
  3. 3Caffeine Therapy in Preterm Neonates: Mechanisms, Clinical Applications, and Long-term Outcomes – A Narrative Review2025
  4. 4Comparison of the Efficacy of Caffeine with Aminophylline for Management of Infants having Apnea of Prematurity2025
  5. 5Recurrence of apnea of prematurity following early discontinuation of caffeine: A prospective analytical study2025