High Vs Low Dose Caffeine in Management of Apnea of Prematurity: A Single-Center Observational Study

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Observational study compares high and low dose caffeine effects on oxygenation and NICU stay.

High dose caffeine effectively reduces the duration of oxygenation in preterm infants, improving outcomes overall.
Statistical analysis showed significant reductions in NICU stay duration (p value 0.03) for high dose caffeine users.
Observational study included preterm infants under 34 weeks gestation with tracked apnoea episodes and other metrics.
Findings support the use of higher caffeine doses without increasing side effects, suggesting better management of apnea.

Shroff et al. (2025) studied this question.

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