August 16, 2025

Identification of a prognostic signature consisting of three macrophage-related genes for glioblastoma based on bulk and single-cell transcriptomes analyses.

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Analysis reveals three macrophage-related genes associated with prognosis in glioblastoma, suggesting new therapeutic insights.

A three-gene signature predicts prognosis in glioblastoma, enhancing understanding of treatment resistance.
The identified genes ISG20, PARP12, and IFIT5 show significant association with immune responses in GBM.
Analysis utilized bulk and single-cell RNA-seq data from over 500 glioblastoma patients, ensuring robust results.
Insights gained may inform future therapies targeting immune checkpoint blockade in glioblastoma.

Wu et al. (2025) studied this question.

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