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September 5, 2025Tropical Journal of Natural Product ResearchOpen Access

Antidiabetic Activity and in silico Molecular Docking of GC-MS- Identified Compounds in Chromatographic Fractions of Tephrosia bracteolata Guill. Perr. (Fabaceae) Leaves

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Authors

PIPrecious A. IdakwojiJOJoan Mayowa OniemolaDZDavid Adeiza Zakari

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Overview

Observational analysis reveals strong antidiabetic effects of GC-MS identified compounds in Tephrosia bracteolata leaves, suggesting potential for diabetes management.

Key Points

  • Significant decrease in fasting blood sugar observed with SF5 in mice, showing up to 38.37% reduction post-treatment.
  • Sub-fractions of ethylacetate from Tephrosia bracteolata leaves exhibited notable antidiabetic activity at 200 and 400 mg/kg doses.
  • Molecular docking techniques identified key compounds binding to diabetes-related targets, including alpha-glucosidase and SGLT 2.
  • Phytochemical analysis confirmed multiple bioactive compounds in the effective sub-fractions, supporting their potential therapeutic applications.

Cite This Study

Idakwoji et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477bed1https://doi.org/10.26538/tjnpr/v9i8.31
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