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September 5, 2025CureusOpen Access

Evaluating the Renal Implications of Intensive Versus Standard Blood Pressure Control in Chronic Kidney Disease: A Systematic Review of Randomized Trials

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Authors

KLKirshan LalAMAhmad MohammadMTMuhammad Umar Tariq

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Overview

Systematic review reveals intense blood pressure control impacts renal results in CKD, indicating individualized approaches improve outcomes.

Key Points

  • Intensive blood pressure control improved proteinuria but increased eGFR decline in certain patients.
  • Among the four studies, eGFR decline hazard ratio reached approximately 4.5 in non-albuminuric subjects.
  • The study followed 20,803 participants over median follow-up times of 2 to 3.2 years.
  • Tailoring blood pressure goals to albuminuria levels may enhance renal benefits while ensuring cardiovascular safety.

Cite This Study

Lal et al. (2025) studied this question.

synapsesocial.com/papers/68c23965b210217d6477b6dbhttps://doi.org/10.7759/cureus.91323
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intensive vs. Less Intensive Blood Pressure Control in Chronic Kidney Disease: A Systematic Review and Meta-analysis of Clinical Trials2025
  2. 2BLOOD PRESSURE LEVELS AND THE PROGRESSION OF CHRONIC KIDNEY DISEASE: A SYSTEMATIC REVIEW2025
  3. 3Effects of Intensive Systolic Blood Pressure Control on Kidney Outcomes in Patients With and Without <scp>CKD</scp>: A Post Hoc Analysis of <scp>SPRINT</scp> and <scp>ACCORD</scp>‐<scp>BP</scp> Trials2025
  4. 4Pros and cons of lower blood pressure targets in chronic kidney disease2025
  5. 5Effects of intensive blood pressure control on cardio-kidney outcomes by KDIGO risk categories: a Post Hoc analysis of ACCORD-BP and SPRINT trials2026