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September 5, 2025Translational PsychiatryOpen Access

Treatments of depressive symptoms in cancer patients: A systematic review and network meta-analysis

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Authors

WFWenhai FuYLYuexin LiuYJYu Jiang

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Overview

Systematic review evaluates pharmacological and non-pharmacological interventions for depression in cancer patients, indicating potential benefits of some therapies.

Key Points

  • Non-pharmacological interventions like massage and relaxation therapy show promise in reducing depressive symptoms.
  • Among pharmacological treatments, the combination of mirtazapine and methylphenidate indicated significant improvement compared to placebo.
  • A total of 95 trials involving 17,260 participants were analyzed, highlighting the variability and low quality of evidence.
  • Further rigorous research is needed to confirm these findings and enhance clinical application for cancer patients.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477aedfhttps://doi.org/10.1038/s41398-025-03507-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Effects of Different Types of Exercise Interventions on Depression in Patients With Cancer: A Network Meta‐Analysis of Randomized Controlled Studies2025
  2. 2Effect of nonpharmacologic therapies on depressive symptoms in patients with chronic fatigue syndrome: a network meta-analysis2025
  3. 3Enhancing depression management in older cancer patients: the pharmacist’s role2025
  4. 4Practical non-pharmacological interventions to improve quality of life for cancer patients and caregivers2025
  5. 5Non-pharmacological therapies for quality of life in women with breast cancer: a protocol for a systematic review and network meta-analysis2025