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September 5, 2025Open Access

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

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Authors

JHJan HomannRKRoxanna Korologou‐LindenVVVivian Viallon

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Overview

Observational analysis identified biomarkers in ALS patients, suggesting early immune, muscular, and metabolic changes.

Key Points

  • Significant pre-diagnostic biomarkers for ALS were detected up to two decades before diagnosis, indicating early physiological changes.
  • Five proteins showed potential as early biomarkers, with pre-diagnosis involvement of immune, muscle, and metabolic systems emphasized.
  • Analysis involved high-throughput proteomic profiling from the EPIC cohort, assessing 7,285 protein markers among 4,567 participants.
  • Findings support novel therapeutic targets for ALS and underscore the need for early intervention strategies in neurodegenerative diseases.

Cite This Study

Homann et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477a670https://doi.org/10.1101/2025.08.20.25334061
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