Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Open Access

Redefining ALS: Large-scale proteomic profiling reveals a prolonged pre-diagnostic phase with immune, muscular, metabolic, and brain involvement

View Full Paper
Ask AI
Bookmark
Share

Authors

CLChristina M. LillJHJan HomannRKRoxanna Korologou‐Linden

Discussion

Loading...

Member takes

Overview

Cohort study identifies biomarkers for ALS, revealing immune and metabolic involvement before diagnosis.

Key Points

  • Pre-diagnostic biomarkers for ALS were identified, pointing to significant immune and metabolic involvement.
  • Five proteins were detected as significant ALS biomarkers more than 20 years prior to clinical diagnosis.
  • Using high-throughput proteomic profiling, analysis in the EPIC cohort linked biomarkers to ALS onset.
  • Findings suggest that early intervention strategies could be developed based on these molecular changes.

Cite This Study

Lill et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477ca38https://doi.org/10.21203/rs.3.rs-7452736/v1
View Full Paper
Ask AI
Bookmark
Share