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October 1, 2025Journal of Heterocyclic Chemistry

Synthesis and Characterization of Biologically Active 1,2,4‐Triazole‐Naphthyridine Scaffolds as Potential Anticancer Agents

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Authors

SVShaganti VenkateshKSKavati ShireeshaKJKumara Swamy Jella

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Overview

Synthesis reports potent anticancer effects in human cancer cell lines, suggesting naphthyridines may be promising candidates.

Key Points

  • Two new compounds exhibited significant anticancer activity, with the highest potency found in 6b at 6.64 μM against MCF‐7.
  • Biological evaluations were conducted using the MTT assay method on four different human cancer cell lines.
  • SAR studies indicated that electron-donating groups enhance anticancer activity, while electron-withdrawing groups decrease potency.
  • The synthesized triazole-naphthyridine derivatives demonstrated overall promising anticancer effects across various cell lines.

Cite This Study

Venkatesh et al. (2025) studied this question.

synapsesocial.com/papers/68dd89d7fe798ba2fc497a6ehttps://doi.org/10.1002/jhet.70109
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