September 5, 2025Scientific ReportsOpen Access

Cell-Free bone regeneration using dental MSCs secretomes from pulp and gingiva in rabbit tibial defects

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HDPSc secretomes significantly improved bone regeneration compared to hGMSC and control groups.
The mineral apposition rate was higher in hDPSCs-treated defects, showcasing enhanced new bone formation.
Histomorphometric measurements revealed increased mature bone area at 3 weeks with hDPSCs secretomes.
Both secretomes effectively upregulated osteocalcin, suggesting strong osteogenic potential.

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Implication

This study demonstrates improved bone repair with hDPSCs secretomes over hGMSCs in rabbit tibial defects, indicating their potential for regenerative therapies.

Cite This Study

Kamal et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64779da9 https://doi.org/10.1038/s41598-025-15924-7

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Implication

This study demonstrates improved bone repair with hDPSCs secretomes over hGMSCs in rabbit tibial defects, indicating their potential for regenerative therapies.

Cell-Free bone regeneration using dental MSCs secretomes from pulp and gingiva in rabbit tibial defects

Key Points

Discussion

Implication

Cite This Study

Cell-Free bone regeneration using dental MSCs secretomes from pulp and gingiva in rabbit tibial defects

Key Points

Discussion

Implication

Cite This Study

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