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September 10, 2025Advanced ScienceOpen Access

Sympathetic Activation Promotes Kidney Fibrosis in Mice via Macrophage‐Derived N2ICD‐Enriched Extracellular Vesicles

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Authors

HRHuiwen RenYHYayan HouCMChengsen Mu

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Overview

Experimental observations reveal that sympathetic nervous system activity influences kidney fibrosis in mice, suggesting therapeutic strategies targeting macrophage interactions.

Key Points

  • Kidney fibrosis is promoted by sympathetic activation via macrophage-derived extracellular vesicles.
  • Norepinephrine-treated macrophages enhance renal fibroblast activation through N2ICD-enriched vesicles.
  • Depleting macrophages significantly reduces kidney fibrosis in mice after ischemia-reperfusion injury.
  • Inhibiting Notch2 in macrophages protects against kidney fibrosis, highlighting possible therapeutic targets.

Cite This Study

Ren et al. (2025) studied this question.

synapsesocial.com/papers/68c23caeb210217d64789ea6https://doi.org/10.1002/advs.202504607
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