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September 5, 2025Molecular Cancer Research

Mapping the FOXA1 Interactome in ER+ Breast Cancer Cells using Proximity Labeling Reveals Novel Interactions with the Orphan Nuclear Receptor NR2C2

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Authors

RPRosemary N. PlagensCTCarla R. TiradoSLShen Li

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Overview

This research demonstrates FOXA1's role in ER+ breast cancer, revealing significant interactions with NR2C2, suggesting new therapeutic targets.

Key Points

  • Novel interactions between FOXA1 and NR2C2 are identified, which may be significant markers for ER+ breast cancer prognosis.
  • The study recovered 157 new FOXA1 interactors, highlighting its broader protein interaction network beyond previously known partners.
  • Systems Biology approaches, including proximity labeling and quantitative proteomics, accurately mapped the FOXA1 interactome in MCF-7 cells.
  • These insights into FOXA1's interactions encourage further research into new biomarkers and treatment options in hormone-driven tumors.

Cite This Study

Plagens et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d6477984dhttps://doi.org/10.1158/1541-7786.mcr-25-0085
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FOXM1 Expression in Invasive Ductal Breast Carcinoma of No Special Type: Insights from RNA-seq and Immunohistochemical Analysis2025
  2. 2Targeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output Program in Prostate Cancer2025
  3. 3FOXC1 expression profile in invasive breast carcinomas and its relationship with prognostic parameters2025
  4. 4Targeting FOXK2 in triple-negative breast cancer: Role of the P53/MCAS1/miR-211–5p regulatory axis2025
  5. 5SOX2 utilizes FOXA1 as a heteromeric transcriptional partner to drive proliferation in therapy-resistant prostate cancer2025 · 2 citations